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Submit ReviewMRS 5698
Discontinued Product
5428 has been discontinued.
View all Adenosine A<sub>3</sub> Receptors products.
Description: High affinity and selective A3 agonist
Chemical Name: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Purity: ≥95% (HPLC)
Biological Activity for MRS 5698
MRS 5698 is a high affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.
Technical Data for MRS 5698
| M. Wt | 564.97 |
| Formula | C28H23ClF2N6O3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1377273-00-1 |
| PubChem ID | 57523213 |
| InChI Key | LYLLLJJYBWLGHW-CIZVZKTGSA-N |
| Smiles | O=[C@](NC)[C@@]1(C2)[C@H]2[C@@H](N3C(N=C(C#CC6=CC(F)=C(F)C=C6)N=C4NCC5=CC(Cl)=CC=C5)=C4N=C3)[C@H](O)[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MRS 5698
References for MRS 5698
References are publications that support the biological activity of the product.
Little et al (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain 138 28 PMID: 25414036
Tosh et al (2012) Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 55 4847 PMID: 22559880
Tosh et al (2015) Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 11 371 PMID: 26111639
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Keywords: MRS 5698, MRS 5698 supplier, High, affinity, selective, A3, adenosine, receptors, agonists, antinociceptive, MRS5698, Adenosine, Receptors, 5428, Tocris Bioscience
2 Citations for MRS 5698
Citations are publications that use Tocris products. Selected citations for MRS 5698 include:
Lei et al (2018) Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration. J Mol Med (Berl) 96 1049-1060 PMID: 30088034
Fong et al (2019) Antitumor effects of MRS5698, a cordycepin derivative, on endometrial cancer cells Natural Product Communications 14 1
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