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Submit ReviewMRT 10
Description: Smoothened (Smo) antagonist
Chemical Name: N-[[[3-Benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxybenzamide
Purity: ≥98%
Biological Activity for MRT 10
MRT 10 is a smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC50 = 2.5 μM); acts as an inverse agonist during nontranscriptional Hedgehog pathway activation (IC50 = 2.5 μM in HEK293 cells).
Technical Data for MRT 10
| M. Wt | 465.52 |
| Formula | C24H23N3O5S |
| Storage | Store at +4°C |
| Purity | ≥98% |
| CAS Number | 330829-30-6 |
| PubChem ID | 1139102 |
| InChI Key | KVQVEZQDNHMQJV-UHFFFAOYSA-N |
| Smiles | O=C(NC(NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2)=S)C1=CC(OC)=C(OC)C(OC)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MRT 10
References for MRT 10
References are publications that support the biological activity of the product.
Solinas et al (2012) Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 55 1559 PMID: 22268551
Manetti et al (2010) Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol.Pharmacol. 78 658 PMID: 20664000
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Keywords: MRT 10, MRT 10 supplier, MRT10, smoothened, receptor, antagonists, inhibitors, inhibits, hedgehog, pathway, inverse, agonists, nontranscriptional, Gli, Shh, sonic, Smoothened, Receptors, Hedgehog, Signaling, 4585, Tocris Bioscience
Citations for MRT 10
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Currently there are no citations for MRT 10.
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