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Submit ReviewMS 21570
Description: GPR171 antagonist
Chemical Name: N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
Purity: ≥98% (HPLC)
Biological Activity for MS 21570
MS 21570 is a GPR171 antagonist (IC50 = 220 nM). Inhibits BigLEN (Cat.No. 6304) mediated increases in [35S]GTPγS binding in hypothalamic membranes and hyperpolarization of basolateral amygdala pyramidal neurons. Reduces anxiety-like behavior and fear conditioning in mice.
Compound Libraries for MS 21570
MS 21570 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for MS 21570
| M. Wt | 237.34 |
| Formula | C10H11N3S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 65373-29-7 |
| PubChem ID | 805117 |
| InChI Key | KFLNRVSOQJTXDG-UHFFFAOYSA-N |
| Smiles | CNC1=NN=C(S1)SCC2=CC=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MS 21570
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.73 | 100 | |
| ethanol | 23.73 | 100 |
Preparing Stock Solutions for MS 21570
The following data is based on the product molecular weight 237.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.21 mL | 21.07 mL | 42.13 mL |
| 5 mM | 0.84 mL | 4.21 mL | 8.43 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.21 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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Product Datasheets for MS 21570
References for MS 21570
References are publications that support the biological activity of the product.
Bobeck et al (2017) The BigLEN-GPR171 peptide receptor system within the basolateral amygdala regulates anxiety-like behavior and contextual fear conditioning. Neuropsychopharmacology 42 2527 PMID: 28425495
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Keywords: MS 21570, MS 21570 supplier, MS21570, GPR171, antagonists, antagonism, bigLEN, anxiety, 6298, Tocris Bioscience
1 Citation for MS 21570
Citations are publications that use Tocris products. Selected citations for MS 21570 include:
Richard D et al (2021) The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Nat Commun 12 5857 PMID: 34615877
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Reviews for MS 21570
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