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Submit ReviewN-Formyl-Met-Leu-Phe
Description: Endogenous FPR1 agonist
Alternative Names: fMLP
Purity: ≥95% (HPLC)
Biological Activity for N-Formyl-Met-Leu-Phe
N-Formyl-Met-Leu-Phe is an endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Stimulates aggregation of leukocytes.
Technical Data for N-Formyl-Met-Leu-Phe
| M. Wt | 437.55 |
| Formula | C21H31N3O5S |
| Sequence |
MLF (Modifications: Met-1 = N-formyl-Met) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 59880-97-6 |
| PubChem ID | 443295 |
| InChI Key | PRQROPMIIGLWRP-BZSNNMDCSA-N |
| Smiles | CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for N-Formyl-Met-Leu-Phe
| Solubility | Soluble to 4 mg/ml in DMSO |
Product Datasheets for N-Formyl-Met-Leu-Phe
References for N-Formyl-Met-Leu-Phe
References are publications that support the biological activity of the product.
Kreutzer et al (1978) Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors. Immunopharmacology 1 39 PMID: 45788
Mills et al (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J.Biol.Chem. 275 39012 PMID: 10960471
Spilberg et al (1984) Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe. Inflammation 8 73 PMID: 6325345
If you know of a relevant reference for N-Formyl-Met-Leu-Phe, please let us know.
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Keywords: N-Formyl-Met-Leu-Phe, N-Formyl-Met-Leu-Phe supplier, Endogenous, FPR1, agonists, FPRL, Formyl, Peptide, Receptors, fMLP, fMLF, 1921, Tocris Bioscience
2 Citations for N-Formyl-Met-Leu-Phe
Citations are publications that use Tocris products. Selected citations for N-Formyl-Met-Leu-Phe include:
Ding et al (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017 2642549 PMID: 28804219
Tomilov et al (2010) Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem 285 1153 PMID: 19892704
Do you know of a great paper that uses N-Formyl-Met-Leu-Phe from Tocris? Please let us know.
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