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Submit ReviewNAD 299 hydrochloride
Description: Selective, high affinity 5-HT1A antagonist
Chemical Name: (3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for NAD 299 hydrochloride
NAD 299 hydrochloride is a selective, high affinity 5-HT1A receptor antagonist (Ki = 0.6 nM in vitro). Enhances the action of selective 5-HT reuptake inhibitors and reverses citalopram-induced (Cat. No. 1427) inhibition of serotonergic cell firing.
Licensing Information
Sold for research purposes under agreement from AstraZeneca
Compound Libraries for NAD 299 hydrochloride
NAD 299 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NAD 299 hydrochloride
| M. Wt | 354.85 |
| Formula | C18H23FN2O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 184674-99-5 |
| PubChem ID | 90488823 |
| InChI Key | GSZJANKLCPHEEX-BTQNPOSSSA-N |
| Smiles | FC1=C2C(C[C@@H](N(C4CCC4)C3CCC3)CO2)=C(C(N)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NAD 299 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 35.48 | 100 | |
| DMSO | 35.48 | 100 |
Preparing Stock Solutions for NAD 299 hydrochloride
The following data is based on the product molecular weight 354.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.09 mL | 28.18 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for NAD 299 hydrochloride
References for NAD 299 hydrochloride
References are publications that support the biological activity of the product.
Larsson et al (1998) Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists. Eur.J.Pharmacol. 346 209 PMID: 9652362
Arborelius et al (1999) The 5-HT1A receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing. Eur.J.Pharmacol. 382 133 PMID: 10528148
Johansson et al (1997) The pharmacological characterization of a novel selective 5-hydroxytryptamine-1A receptor antagonist, NAD-299. J.Pharmacol.Exp.Ther. 283 216 PMID: 9336327
If you know of a relevant reference for NAD 299 hydrochloride, please let us know.
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Keywords: NAD 299 hydrochloride, NAD 299 hydrochloride supplier, AstraZeneca, 5-HT1A, serotonin, 5-HT, receptor, antagonists, NAD299, Receptors, 3282, Tocris Bioscience
1 Citation for NAD 299 hydrochloride
Citations are publications that use Tocris products. Selected citations for NAD 299 hydrochloride include:
Afshar et al (2019) Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease. J.Chem.Neuroanat. 96 140
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.