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Submit ReviewNAV 26
Discontinued Product
4691 has been discontinued.
View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
Description: Selective Nav1.7 channel blocker
Chemical Name: 2,3-Dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for NAV 26
NAV 26 is a selective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
Compound Libraries for NAV 26
NAV 26 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NAV 26
| M. Wt | 434.41 |
| Formula | C22H21F3N2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1198160-14-3 |
| PubChem ID | 44540282 |
| InChI Key | ICGMZCVSHDKQTE-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC=C1C(C(NCC4=CC=C(OC(F)(F)F)C=C4)=O)N2C3CCOCC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NAV 26
References for NAV 26
References are publications that support the biological activity of the product.
Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866 PMID: 22770500
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Keywords: NAV 26, NAV 26 supplier, NAV26, selective, NAv1.7, ion, channels, blockers, Voltage-gated, Sodium, Channels, 4691, Tocris Bioscience
1 Citation for NAV 26
Citations are publications that use Tocris products. Selected citations for NAV 26 include:
Dandan et al (2017) Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3β signaling pathway. Mol Med Rep 16 2269-2273 PMID: 28627683
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