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Submit ReviewNCX 4040
Description: NO-donating aspirin; anti-inflammatory and antitumor
Chemical Name: 2-(Acetyloxy)benzoic acid 4-[(nitrooxy)methyl]phenyl ester
Purity: ≥98% (HPLC)
Biological Activity for NCX 4040
NCX 4040 is a NO-donating aspirin; anti-inflammatory. Blocks inflammatory mediator production in isolated human monocytes (IC50 values are 0.07, 0.13, 0.15 and 0.18 μM for IL-1β, PGE2, IL-10 and TNF-α respectively). Decreases COX-2 expression (IC50 = 0.13 μM); disrupts proteasome-mediated degradation of iκB-α. Antiproliferative in HCT116 colon cancer cells; sensitizes drug-resistant ovarian tumor cells to cisplatin (Cat. No. 2251).
Technical Data for NCX 4040
| M. Wt | 331.28 |
| Formula | C16H13NO7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 287118-97-2 |
| PubChem ID | 9818919 |
| InChI Key | CTHNKWFUDCMLIQ-UHFFFAOYSA-N |
| Smiles | O=C(C)OC1=C(C(OC2=CC=C(CO[N+]([O-])=O)C=C2)=O)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NCX 4040
References for NCX 4040
References are publications that support the biological activity of the product.
Ricciotti et al (2010) NCX 4040, a nitric oxide-donating aspirin, exerts anti-inflammatory effects through inhibition of I kappa B-alpha degradation in human monocytes. J.Immunol. 184 2140 PMID: 20065114
Yamakawa et al (2008) Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism. Biol.Pharm.Bull. 31 916 PMID: 18451518
Bratasz et al (2008) NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisp. by depletion of cellular thiols. J.Transl.Med. 6 9 PMID: 18302761
Gao et al (2008) Immunomodulatory activity of synthetic triterpenoids: inhibition of lymphocyte proliferation, cell-mediated cytotoxicity, and cytokine gene expression through suppression of NF-κB. Immunopharmacol.Immunotoxicol. 30 581 PMID: 18608528
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Keywords: NCX 4040, NCX 4040 supplier, NCX4040, NO, nitric, oxide, donating, donors, aspirin, para, cyclooxygenase, inhibitors, inhibits, anti-inflammatory, inflammation, NSAIDs, antitumor, cisplatin, resistant, Cyclooxygenase, Donors, /, Precursors, 4531, Tocris Bioscience
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