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View all General Calcium Signaling Agents products.Ned K is a NAADP inhibitor. Prevents Ca2+ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca2+ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.
M. Wt | 521.61 |
Formula | C31H31N5O3 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 2250019-90-8 |
PubChem ID | 127021041 |
InChI Key | LMTWTJMBOFXQTH-LITSAYRRSA-N |
Smiles | O=C(O)[C@H]1N[C@H](C2=CC=C(OC)C(CN3CCN(C4=CC=CC=C4C#N)CC3)=C2)C5=C(C(C=CC=C6)=C6N5)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Davidson et al (2015) Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc.Res. 108 357 PMID: 26395965
Keywords: Ned K, Ned K supplier, Nedk, NAADP, signaling, inhibitors, inhibits, nicotinic, acid, adenine, dinucleotide, phosphate, cardioprotectant, calcium, Ca2+, General, Calcium, Signaling, Agents, 5976, Tocris Bioscience
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