Home / Cell Biology / Signal Transduction / Calcium Signaling / General Calcium Signaling Agents / Ned K

Ned K

Cat. No. 5976 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Prevents Ca2+ oscillations in cardiomyocytes during ischemia/reperfusion; NAADP signaling inhibitor
Chemical Name: (1R,3S)-1-[3-[[4-(2-Cyanophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Ned K

Ned K is a NAADP inhibitor. Prevents Ca2+ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca2+ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.

Technical Data for Ned K

M. Wt 521.61
Formula C31H31N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250019-90-8
PubChem ID 127021041
InChI Key LMTWTJMBOFXQTH-LITSAYRRSA-N
Smiles O=C(O)[C@H]1N[C@H](C2=CC=C(OC)C(CN3CCN(C4=CC=CC=C4C#N)CC3)=C2)C5=C(C(C=CC=C6)=C6N5)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ned K

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.08 50

Preparing Stock Solutions for Ned K

The following data is based on the product molecular weight 521.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.83 mL 19.17 mL 38.34 mL
2.5 mM 0.77 mL 3.83 mL 7.67 mL
5 mM 0.38 mL 1.92 mL 3.83 mL
25 mM 0.08 mL 0.38 mL 0.77 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Ned K

References are publications that support the biological activity of the product.

Davidson et al (2015) Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc.Res. 108 357 PMID: 26395965

If you know of a relevant reference for Ned K, please let us know.

View Related Products by Target

Keywords: Ned K, Ned K supplier, Nedk, NAADP, signaling, inhibitors, inhibits, nicotinic, acid, adenine, dinucleotide, phosphate, cardioprotectant, calcium, Ca2+, General, Calcium, Signaling, Agents, 5976, Tocris Bioscience

Citations for Ned K

Citations are publications that use Tocris products.

Currently there are no citations for Ned K. Do you know of a great paper that uses Ned K from Tocris? Please let us know.

Reviews for Ned K

There are currently no reviews for this product. Be the first to review Ned K and earn rewards!

Have you used Ned K?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review