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Submit ReviewNeurokinin B (human, porcine)
Description: Endogenous tachykinin peptide
Alternative Names: NKB
Purity: ≥95% (HPLC)
Biological Activity for Neurokinin B (human, porcine)
Neurokinin B (human, porcine) is an endogenous tachykinin agonist peptide that shows preference for the NK3 receptor (EC50 = 1 nM).
Technical Data for Neurokinin B (human, porcine)
| M. Wt | 1210.43 |
| Formula | C55H79N13O14S2 |
| Sequence |
DMHDFFVGLM (Modifications: Met-10 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 86933-75-7 |
| PubChem ID | 5311312 |
| InChI Key | NHXYSAFTNPANFK-HDMCBQFHSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Neurokinin B (human, porcine)
| Solubility | Soluble to 1 mg/ml in DMSO |
Product Datasheets for Neurokinin B (human, porcine)
References for Neurokinin B (human, porcine)
References are publications that support the biological activity of the product.
Laufer et al (1985) Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc.Natl.Acad.Sci.U.S.A. 82 7444 PMID: 2414777
Severini et al (2002) The tachykinin peptide family. Pharmacol.Rev. 54 285 PMID: 12037144
Wang et al (2001) Neurokinin B potentiates ATP-activated currents in rat DRG neurons. Brain Res. 923 157 PMID: 11743983
If you know of a relevant reference for Neurokinin B (human, porcine), please let us know.
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Keywords: Neurokinin B (human, porcine), Neurokinin B (human, porcine) supplier, Endogenous, tachykinin, peptide, Non-Selective, Neurokinin, Receptors, NeurokininB, (human, porcine), NKB, Other, Tachykinin, 1582, Tocris Bioscience
1 Citation for Neurokinin B (human, porcine)
Citations are publications that use Tocris products. Selected citations for Neurokinin B (human, porcine) include:
Weems et al (2018) Evidence That Dynorphin Acts Upon KNDy and GnRH Neurons During GnRH Pulse Termination in the Ewe. Endocrinology 159 3187 PMID: 30016419
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.