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Submit ReviewNeuromedin S (rat)
Description: Potent, endogenous NMU1 and NMU2 agonist
Biological Activity for Neuromedin S (rat)
Neuromedin S (rat) is a potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent endogenous anorexigenic peptide.
Technical Data for Neuromedin S (rat)
| M. Wt | 4241.97 |
| Formula | C193H307N57O49S |
| Sequence |
LPRLLHTDSRMATIDFPKKDPTTSLGRPFFLFRPRN (Modifications: Asn-36 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 843782-19-4 |
| PubChem ID | 90488896 |
| InChI Key | FJADBVUPVZKUEP-OFGSCBOVSA-N |
| Smiles | [H]N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Neuromedin S (rat)
References for Neuromedin S (rat)
References are publications that support the biological activity of the product.
Mori et al (2005) Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J. 24 325 PMID: 15635449
Ida et al (2005) Neuromedin S is a novel anorexigenic hormone. Endocrinology 146 4217 PMID: 15976061
Mitchell et al (2009) Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. Br.J.Pharmacol. 158 87 PMID: 19519756
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Keywords: Neuromedin S (rat), Neuromedin S (rat) supplier, Potent, endogenous, NMU1, and, NMU2, agonists, Neuromedin, U, Receptors, NeuromedinS, (rat), circadian, rhythms, 3648, Tocris Bioscience
1 Citation for Neuromedin S (rat)
Citations are publications that use Tocris products. Selected citations for Neuromedin S (rat) include:
Sampson et al (2018) Small-Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models. Pharmacol Res Perspect 6 e00425 PMID: 30151213
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