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Submit ReviewNeuromedin U (rat)
Description: Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature
Biological Activity for Neuromedin U (rat)
Endogenous peptide regulating blood pressure, ion transport in the gut, mesenteric blood flow and adrenocortical function. Also decreases food intake and body weight, increases body temperature and heat production, and inhibits gastric acid secretion via the CRH system following central administration in vivo.
Technical Data for Neuromedin U (rat)
| M. Wt | 2643 |
| Formula | C124H180N34O31 |
| Sequence |
YKVNEYQGPVAPSGGFFLFRPRN (Modifications: Asn-23 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 117505-80-3 |
| PubChem ID | 71311710 |
| InChI Key | YYDRKWCPVLDJJD-XOXVDEAXSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Neuromedin U (rat)
References for Neuromedin U (rat)
References are publications that support the biological activity of the product.
Minamino et al (1985) Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 130 1078 PMID: 3841690
Mondal et al (2003) Neuromedin U acts in the cental nervous system to inhibit gastric acid secretion via CRH system. Am.J.Physiol.Gastrointest.Liver Physiol. 284 G963 PMID: 12584108
Szekeres et al (2000) Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J.Biol.Chem. 275 20247 PMID: 10811630
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Keywords: Neuromedin U (rat), Neuromedin U (rat) supplier, NMU, Receptors, agonists, NeuromedinU, (rat), Neuromedin, U, 1917, Tocris Bioscience
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