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Submit ReviewNeuropeptide AF (human)
Description: Endogenous NPFF1 and NPFF2 agonist; antiopioid neuropeptide and MRGPRA agonist
Alternative Names: NPAF,Neuropeptide NPAF (human FMRFamide-related)
Biological Activity for Neuropeptide AF (human)
Neuropeptide AF (human) is an endogenous antiopioid neuropeptide and agonist at NPFF1 and NPFF2 receptors. Implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes. Also MRGPRA agonist
Technical Data for Neuropeptide AF (human)
| M. Wt | 1978.19 |
| Formula | C90H132N26O25 |
| Sequence |
AGEGLNSQFWSLAAPQRF (Modifications: Phe-18 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 192387-38-5 |
| PubChem ID | 90488726 |
| InChI Key | DYSIROANKWMSGC-KWFINLGMSA-N |
| Smiles | [H]N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Neuropeptide AF (human)
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References for Neuropeptide AF (human)
References are publications that support the biological activity of the product.
Elshourbagy et al (2000) Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J.Biol.Chem. 275 25965 PMID: 10851242
Lefrere et al (2002) Neuropeptide AF and FF modulation of adipocyte metabolism. J.Biol.Chem. 277 39169 PMID: 12149260
Vilim et al (1999) Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli. Mol.Pharmacol. 55 804 PMID: 10220558
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
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Keywords: Neuropeptide AF (human), Neuropeptide AF (human) supplier, Implicated, pain, modulation, antiopioid, neuropeptides, FF, AF, NPFF, Receptors, NPFF1, NPFF2, endogenous, agonists, MRGPRA, mas-related, gene, protein, coupled, agonism, NPAF, Neuropeptide, (human, FMRFamide-related), Miscellaneous/Non-selective, Opioids, FF/AF, Mas-related, G, Protein-Coupled, 1928, Tocris Bioscience
Citations for Neuropeptide AF (human)
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