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Submit ReviewNeuropeptide SF (mouse, rat)
Description: NPFF1 and NPFF2 agonist
Biological Activity for Neuropeptide SF (mouse, rat)
Neuropeptide SF (mouse, rat) is a neuropeptide FF receptor agonist (Ki values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC50 ~ 50 μM).
Technical Data for Neuropeptide SF (mouse, rat)
| M. Wt | 888.03 |
| Formula | C40H65N13O10 |
| Sequence |
SLAAPQRF (Modifications: Phe-8 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 230960-31-3 |
| PubChem ID | 90488868 |
| InChI Key | OLOSAWFREOVGQW-CJKZIAQFSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Neuropeptide SF (mouse, rat)
References for Neuropeptide SF (mouse, rat)
References are publications that support the biological activity of the product.
Deval et al (2003) Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 44 662 PMID: 12668052
Jhamandas et al (2006) Facilitation of spinal mor. analgesia in normal and mor. tolerant animals by neuropeptide SF and related peptides. Peptides 27 953 PMID: 16515821
Gouarderes et al (2002) Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [125I]EYF as selective radioligands. Neurosci. 115 349
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Keywords: Neuropeptide SF (mouse, rat), Neuropeptide SF (mouse, rat) supplier, NPFF1, NPFF2, agonists, Neuropeptides, FF, AF, Receptors, FF/AF, acid, sensing, ion, channel, 3, ASIC3, NeuropeptideSF, (mouse, rat), npffr1, npffr2, ASIC, Neuropeptide, Miscellaneous/Non-selective, Opioids, 3647, Tocris Bioscience
Citations for Neuropeptide SF (mouse, rat)
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