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Submit ReviewNGD 98-2 hydrochloride
Description: High affinity CRF1 antagonist
Chemical Name: N-(1-Ethylpropyl)-3-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-2-pyrazinamine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for NGD 98-2 hydrochloride
NGD 98-2 hydrochloride is a high affinity antagonist of corticotropin-releasing factor receptor 1 (CRF1) (Ki = 1 nM). Orally available and brain penetrant.
Technical Data for NGD 98-2 hydrochloride
| M. Wt | 435.87 |
| Formula | C19H24F3N3O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| PubChem ID | 90488929 |
| InChI Key | KUZDADGRZQAQGN-UHFFFAOYSA-N |
| Smiles | CC1=NC(NC(CC)CC)=C(OC)N=C1C2=CC=C(OC(F)(F)F)C=C2OC.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NGD 98-2 hydrochloride
References for NGD 98-2 hydrochloride
References are publications that support the biological activity of the product.
Hodgetts et al (2011) Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active cortico. releasing factor-1 (CRF-1) receptor antagonist. J.Med.Chem. 54 4187 PMID: 21618986
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Citations for NGD 98-2 hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.