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Submit ReviewNIDA 41020
Description: High affinity CB1 antagonist
Chemical Name: N-(Piperidin-1-yl)-5-(4-methoxyphenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Purity: ≥99% (HPLC)
Biological Activity for NIDA 41020
High affinity CB1 receptor antagonist (Ki = 4.1 nM). Exhibits significantly reduced lipophilicity compared to other CB1 antagonists.
Technical Data for NIDA 41020
| M. Wt | 459.37 |
| Formula | C23H24Cl2N4O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 502486-89-7 |
| PubChem ID | 11037861 |
| InChI Key | KWDBQJRWPWTGPF-UHFFFAOYSA-N |
| Smiles | O=C(NN3CCCCC3)C1=NN(C2=CC=C(Cl)C=C2Cl)C(C4=CC=C(OC)C=C4)=C1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NIDA 41020
References for NIDA 41020
References are publications that support the biological activity of the product.
Katoch-Rouse et al (2003) Synthesis, structure-activity relationship and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity. J.Med.Chem. 46 642 PMID: 12570386
Miller et al (2007) Analogs of SR-141716A (Rimonabant) alter d-amphetamine-evoked [3H] DA overflow from preloaded striatal slices and amphetamine-induced hyperactivity. Life Sci. 81 63 PMID: 17532007
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Keywords: NIDA 41020, NIDA 41020 supplier, NIDA41020, cannabinoid, receptors, antagonists, CB1, selective, Receptors, 3921, Tocris Bioscience
1 Citation for NIDA 41020
Citations are publications that use Tocris products. Selected citations for NIDA 41020 include:
Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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