Nintedanib

Cat. No. 7049 Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Potent VEGFR, PDGFR and FGFR inhibitor

Chemical Name: Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate

Purity: ≥98%

Datasheet

Citations

Reviews

Literature (1)

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Nintedanib

Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC₅₀ values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC₅₀ values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.

Technical Data for Nintedanib

M. Wt	539.64
Formula	C₃₁H₃₃N₅O₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	656247-17-5
PubChem ID	135423438
InChI Key	XZXHXSATPCNXJR-ZIADKAODSA-N
Smiles	COC(=O)C1=CC=C2C(NC(=O)\C2=C(/NC2=CC=C(C=C2)N(C)C(=O)CN2CCN(C)CC2)C2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nintedanib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.08	2 with gentle warming

Preparing Stock Solutions for Nintedanib

The following data is based on the product molecular weight 539.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	92.65 mL	463.27 mL	926.54 mL
0.1 mM	18.53 mL	92.65 mL	185.31 mL
0.2 mM	9.27 mL	46.33 mL	92.65 mL
1 mM	1.85 mL	9.27 mL	18.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Product Datasheets for Nintedanib

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Nintedanib

References are publications that support the biological activity of the product.

Hilberg et al (2008) BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 68 4774 PMID: 18559524

If you know of a relevant reference for Nintedanib, please let us know.

View Related Products by Target

View Related Products by Product Action

View all VEGFR Inhibitors

Keywords: Nintedanib, Nintedanib supplier, BIBF1120, angiokinase, inhibitors, inhibits, VEGFR, PDGFR, FGFR, potent, vascular, endothelial, growth, factor, platelet-derived, fibroblast, angiogenesis, VEGF, FGF, PDGF, 7049, Tocris Bioscience

Citations for Nintedanib

Citations are publications that use Tocris products.

Currently there are no citations for Nintedanib. Do you know of a great paper that uses Nintedanib from Tocris? Please let us know.

Reviews for Nintedanib

There are currently no reviews for this product. Be the first to review Nintedanib and earn rewards!

Have you used Nintedanib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Nintedanib

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.