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Submit ReviewNS 11021
Description: KCa1.1 (BK) channel activator
Chemical Name: N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Purity: ≥98% (HPLC)
Biological Activity for NS 11021
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.
Compound Libraries for NS 11021
NS 11021 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NS 11021
| M. Wt | 511.24 |
| Formula | C16H9BrF6N6S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 956014-19-0 |
| PubChem ID | 24825677 |
| InChI Key | MDKAFDIKYQMOMF-UHFFFAOYSA-N |
| Smiles | BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NS 11021
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 51.12 | 100 | |
| DMSO | 51.12 | 100 |
Preparing Stock Solutions for NS 11021
The following data is based on the product molecular weight 511.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.96 mL | 9.78 mL | 19.56 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.91 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.96 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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Product Datasheets for NS 11021
References for NS 11021
References are publications that support the biological activity of the product.
Layne et al (2009) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R378 PMID: 19923353
Bentzen et al (2007) The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol.Pharmacol. 72 1033 PMID: 17636045
Kun et al (2009) NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats. Br.J.Pharmacol. 158 1465 PMID: 19845682
If you know of a relevant reference for NS 11021, please let us know.
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Keywords: NS 11021, NS 11021 supplier, NS11021, NS_11021, BKCa, KCa1.1, large-conductance, Ca2+-activated, Ca2+-dependent, calcium, potassium, K+, channels, activators, activates, openers, opens, Ca2+-Activated, Potassium, Channels, 4788, Tocris Bioscience
2 Citations for NS 11021
Citations are publications that use Tocris products. Selected citations for NS 11021 include:
Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391 PMID: 28264196
Peter C et al (2022) FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis. J Neurosci 42 1618-1628 PMID: 34996816
Do you know of a great paper that uses NS 11021 from Tocris? Please let us know.
Reviews for NS 11021
Average Rating: 5 (Based on 2 Reviews.)
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The pharmacological inhibitors for electrophysiology assay.
By
Anonymous on 02/28/2020
Assay Type: In Vitro
Species: Other
The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
Great standard calcium activated potassium channel activator for K+ activation experiments.
By
Farzana Islam on 10/06/2018
Assay Type: In Vitro
Species: Human
NS 11021 was used as a standard BK channel opener as it is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). It performed well under lab conditions. Needs to be dissolved in organic solvent, ethanol and DMSO are good options for that.
