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Submit ReviewNS 5806
Description: KV4.3 channel activator
Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
Purity: ≥99% (HPLC)
Biological Activity for NS 5806
NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito). Increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV4.2 and KV4.3 currents in the presence of KChIP2.
Compound Libraries for NS 5806
NS 5806 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NS 5806
| M. Wt | 574.07 |
| Formula | C16H8Br2F6N6O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 426834-69-7 |
| PubChem ID | 11642685 |
| InChI Key | UZWJWROOLOOCPQ-UHFFFAOYSA-N |
| Smiles | BrC1=CC(Br)=CC(C2=NN=NN2)=C1NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NS 5806
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.41 | 100 | |
| ethanol | 28.7 | 50 |
Preparing Stock Solutions for NS 5806
The following data is based on the product molecular weight 574.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.74 mL | 8.71 mL | 17.42 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.48 mL |
| 10 mM | 0.17 mL | 0.87 mL | 1.74 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.35 mL |
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Product Datasheets for NS 5806
References for NS 5806
References are publications that support the biological activity of the product.
Calloe et al (2009) A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc.Res. 81 686 PMID: 19073629
Calloe et al (2010) Differential effects of the transient outward K+ current activator NS5806 in the canine left ventricle. J.Mol.Cell.Cardiol. 48 191 PMID: 19632239
Lundby et al (2010) Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2. Br.J.Pharmacol. 160 2028 PMID: 20649599
If you know of a relevant reference for NS 5806, please let us know.
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Keywords: NS 5806, NS 5806 supplier, NS5806, kv4.3, channels, ito, transient, outward, potassium, currents, activators, voltage-gated, voltage-dependent, K+, Voltage-Gated, Potassium, Channels, 4166, Tocris Bioscience
1 Citation for NS 5806
Citations are publications that use Tocris products. Selected citations for NS 5806 include:
Gonzalez et al (2014) Modulation of the voltage-gated potassium channel (Kv4.3) and the auxiliary protein (KChIP3) interactions by the current activator NS5806. J Biol Chem 289 32201 PMID: 25228688
Do you know of a great paper that uses NS 5806 from Tocris? Please let us know.
Reviews for NS 5806
Average Rating: 4 (Based on 1 Review.)
Have you used NS 5806?
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NS 5806 shows channel opening properties and would use this product again.
By
Sadequl Islam on 10/12/2018
Assay Type: In Vitro
Species: Human
NS 5806 was studied to understand its channel opening properties. The product was dissolved in DMSO and it showed channel opening properties as expected. Performs well in experimental condition. Would recommend and use again.
