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Submit ReviewNS 8593 hydrochloride
Description: Selective negative modulator of KCa2 (SK) channels; inhibits SK currents
Chemical Name: N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for NS 8593 hydrochloride
NS 8593 hydrochloride is a selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.
Compound Libraries for NS 8593 hydrochloride
NS 8593 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for NS 8593 hydrochloride
| M. Wt | 299.8 |
| Formula | C17H17N3.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 875755-24-1 |
| PubChem ID | 71311765 |
| InChI Key | VWEKCDTXUUPBNA-PFEQFJNWSA-N |
| Smiles | C12=CC=CC=C1N=C(N[C@H]3C(C=CC=C4)=C4CCC3)N2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NS 8593 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.98 | 100 | |
| ethanol | 6 | 20 |
Preparing Stock Solutions for NS 8593 hydrochloride
The following data is based on the product molecular weight 299.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.34 mL | 16.68 mL | 33.36 mL |
| 5 mM | 0.67 mL | 3.34 mL | 6.67 mL |
| 10 mM | 0.33 mL | 1.67 mL | 3.34 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
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Product Datasheets for NS 8593 hydrochloride
References for NS 8593 hydrochloride
References are publications that support the biological activity of the product.
Strøbaek et al (2006) Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hip Mol.Pharmacol. 70 1771 PMID: 16926279
Sørensen (2008) Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators of small conductance Ca2+-activated K+ channels. J.Med.Chem. 51 7625 PMID: 18998663
Jenkins et al (2011) Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of KCa2 channels. Mol.Pharmacol. 79 899 PMID: 21363929
If you know of a relevant reference for NS 8593 hydrochloride, please let us know.
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3 Citations for NS 8593 hydrochloride
Citations are publications that use Tocris products. Selected citations for NS 8593 hydrochloride include:
Schmidt et al (2022) Structural mechanism of TRPM7 channel regulation by intracellular magnesium Cell Mol Life Sci 79 225 PMID: 35389104
Tian et al (2018) Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels. J Cell Mol Med 22 6327 PMID: 30338939
Yi et al (2020) TRPM7 activation potentiates SOCE in enamel cells but requires ORAI. Cell Calcium 87 102187 PMID: 32146159
Do you know of a great paper that uses NS 8593 hydrochloride from Tocris? Please let us know.
Reviews for NS 8593 hydrochloride
Average Rating: 5 (Based on 1 Review.)
Have you used NS 8593 hydrochloride?
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NS 8593 worked great on experimental conditions.
By
Sadequl Islam on 10/13/2018
Assay Type: In Vivo
Species: Mouse
Product was used to study SK channel activity. Shows channel blocking activity and reduced Calcium activated opening. Great product, performs well and stable.
The product was dissolved in DMSO. Sterile DMSO must be used for sterile cell culture studies.
