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Submit ReviewNSC 319726 is a reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.
M. Wt | 234.32 |
Formula | C11H14N4S |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 71555-25-4 |
PubChem ID | 5351307 |
InChI Key | XDHBUMNIQRLHGO-UKTHLTGXSA-N |
Smiles | C/C(C1=NC=CC=C1)=N\NC(N2CCC2)=S |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Yu et al (2012) Allele-specific p53 mutant reactivation. Cancer Cell 21 614 PMID: 22624712
Keywords: NSC 319726, NSC 319726 supplier, NSC319726, mutant, p53, reactivators, activators, p53R175, transcription, factors, cell, cycle, apoptosis, 5065, Tocris Bioscience
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This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
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