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NSC 668036

Cat. No. 5813 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein
Chemical Name: N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NSC 668036

NSC 668036 is a Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.

Compound Libraries for NSC 668036

NSC 668036 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for NSC 668036

M. Wt 460.52
Formula C21H36N2O9
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 144678-63-7
PubChem ID 71312060
InChI Key IPICFSFUAKDZEI-AJNGGQMLSA-N
Smiles CC([C@@H](C(O)=O)OC([C@@H](NC([C@H](C(C)C)OC([C@@H](NC(OC(C)(C)C)=O)C)=O)=O)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 668036

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.05 100
ethanol 46.05 100

Preparing Stock Solutions for NSC 668036

The following data is based on the product molecular weight 460.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.86 mL 21.71 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for NSC 668036

References are publications that support the biological activity of the product.

Shan et al (2005) Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 44 15495 PMID: 16300398

Wang et al (2015) Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp.Cell Res. 331 115 PMID: 25445788

If you know of a relevant reference for NSC 668036, please let us know.

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Keywords: NSC 668036, NSC 668036 supplier, NSC668036, Wnt, signaling, inhibitors, inhibits, PDZ, domain, Dishevelled, Dvl, β, beta-catenin, Other, Signaling, 5813, Tocris Bioscience

3 Citations for NSC 668036

Citations are publications that use Tocris products. Selected citations for NSC 668036 include:

Carlos et al (2021) Inhibition of Wnt-β-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells. Front Oncol 11 729228 PMID: 34778043

Ming et al (2022) Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells. Elife 11 PMID: 35018887

Carr et al (2023) The Wnt pathway protein Dvl1 targets Somatostatin receptor 2 for lysosome-dependent degradation. J.Biol.Chem. 299 104645 PMID: 36965619

Do you know of a great paper that uses NSC 668036 from Tocris? Please let us know.

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Pathways for NSC 668036

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.