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Submit ReviewNU 9056
Description: Inhibitor of KAT5 (Tip60)
Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Biological Activity for NU 9056
NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.
Technical Data for NU 9056
| M. Wt | 232.37 |
| Formula | C6H4N2S4 |
| Storage | Store at -20°C |
| CAS Number | 1450644-28-6 |
| PubChem ID | 72201043 |
| InChI Key | MLRAMCAHIWHWRM-UHFFFAOYSA-N |
| Smiles | C1(SSC2=CC=NS2)=CC=NS1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NU 9056
| Solubility | Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml) |
Product Datasheets for NU 9056
References for NU 9056
References are publications that support the biological activity of the product.
Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539 PMID: 23056207
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Keywords: NU 9056, NU 9056 supplier, NU9056, KAT5, Tip60, histone, acetyltransferase, HAT, inhibitors, inhibits, acetylation, dna, damage, proliferation, apoptosis, caspase, Histone, Acetyltransferases, Post-translational, Modifications, 4903, Tocris Bioscience
14 Citations for NU 9056
Citations are publications that use Tocris products. Selected citations for NU 9056 include:
Mirita et al (2023) Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form. Nat Commun 14 2095 PMID: 37055396
Scaglione et al (2018) PRMT5-mediated regulation of developmental myelination. Nat Commun 9 2840 PMID: 30026560
Ho et al (2018) Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells. Neurochem Res 43 540 PMID: 29235036
Narkaj et al (2018) Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. Eneuro 5 PMID: 30417078
Lu et al (2021) NU9056, a KAT 5 Inhibitor, Treatment Alleviates Brain Dysfunction by Inhibiting NLRP3 Inflammasome Activation, Affecting Gut Microbiota, and Derived Metabolites in LPS-Treated Mice. Front Nutr 8 701760 PMID: 34327209
Y et al (2017) Histone 3 lysine 9 acetylation is a biomarker of the effects of culture on zygotes. Reproduction 154 375-385 PMID: 28878090
Takashi et al (2017) Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells. Oncol Rep 38 693-702 PMID: 28677817
Bakshi et al (2017) Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion. Sci Rep 7 3635 PMID: 28623334
Rollins et al (2017) Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. PLoS Genet 13 e1006626 PMID: 28231279
Parira et al (2017) Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac. Sci Rep 7 11236 PMID: 28894190
Emily M et al (2022) The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells. Oncogenesis 11 33 PMID: 35717336
Anthony et al (2019) Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes. Cell Rep 26 3132-3144.e7 PMID: 30865899
Lin et al (2020) Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability. J Clin Invest 130 1431-1445 PMID: 31794431
Shan-Lu et al (2020) Butyrate Reprograms Expression of Specific Interferon-Stimulated Genes. J Virol 94 PMID: 32461320
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.