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Submit ReviewOchratoxin A
Discontinued Product
1291 has been discontinued.
Description: Stimulates SERCA-ATP-dependent Ca2+ pump activity
Chemical Name: N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine
Purity: ≥99% (HPLC)
Biological Activity for Ochratoxin A
Ochratoxin A is a mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.
Technical Data for Ochratoxin A
| M. Wt | 403.82 |
| Formula | C20H18ClNO6 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 303-47-9 |
| PubChem ID | 442530 |
| InChI Key | RWQKHEORZBHNRI-BMIGLBTASA-N |
| Smiles | OC1=C(C(N[C@H]([C@@](O)=O)CC3=CC=CC=C3)=O)C=C(Cl)C2=C1C(O[C@H](C)C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ochratoxin A
References for Ochratoxin A
References are publications that support the biological activity of the product.
Chong and Rahimtula (1992) Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro. Biochem.Pharmacol. 44 1401 PMID: 1417961
Dirheimer and Creppy (1991) Mechanism of action of ochratoxin A. IARC Sci.Publ. 115 171 PMID: 1820332
Gekle et al (2000) Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J.Pharmacol.Exp.Ther. 293 837 PMID: 10869383
Omar et al (1991) Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation. J.Biochem.Toxicol. 6 203 PMID: 1770504
Merck Index 12 6836
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Keywords: Ochratoxin A, Ochratoxin A supplier, Stimulates, stimulators, SERCA-ATPase, Ca2+, pump, activity, modulators, Ca2+-ATPase, Calcium-ATPase, Ion, Transporters, Pumps, OchratoxinA, 1291, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Ochratoxin A, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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