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Submit ReviewOleanolic acid
Description: Selective GPBA receptor (TGR5) partial agonist
Chemical Name: (3β)-3-Hydroxyolean-12-en-28-oic acid
Purity: ≥97% (HPLC)
Biological Activity for Oleanolic acid
Oleanolic acid is a GPBA receptor (TGR5) partial agonist (EC50 = 2.25 μM; 72% efficacy). Displays no activity at FXR. Also inhibits protein phosphate 1B (PTP1B) and glycogen phosphorylase. Suppresses cell proliferation and increases apoptosis in T24 bladder cancer cells. Antidiabetic, antihyperglycaemic, antitumor and hepatoprotective.
Technical Data for Oleanolic acid
| M. Wt | 456.7 |
| Formula | C30H48O3 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 508-02-1 |
| PubChem ID | 10494 |
| InChI Key | MIJYXULNPSFWEK-GTOFXWBISA-N |
| Smiles | [H][C@@]12CC(C)(CC[C@]1(C(O)=O)CC[C@@]3(C2=CC[C@@]4([C@]5(CC[C@@H](C(C)([C@@]5(CC[C@@]34C)[H])C)O)C)[H])C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Oleanolic acid
References for Oleanolic acid
References are publications that support the biological activity of the product.
Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178 PMID: 19911773
Mu et al (2015) Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling. Int.J.Clin.Exp.Pathol. 8 13864 PMID: 26823699
Castellano et al (2013) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 62 1791 PMID: 23704520
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Citations for Oleanolic acid
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