Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewOR-486
Description: COMT inhibitor
Chemical Name: 3,5-Dinitrocatechol
Purity: ≥99% (HPLC)
Biological Activity for OR-486
OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase.
Technical Data for OR-486
| M. Wt | 200.11 |
| Formula | C6H4N2O6 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 7659-29-2 |
| PubChem ID | 3870203 |
| InChI Key | VDCDWNDTNSWDFJ-UHFFFAOYSA-N |
| Smiles | OC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OR-486
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 20.01 | 100 | |
| DMSO | 20.01 | 100 |
Preparing Stock Solutions for OR-486
The following data is based on the product molecular weight 200.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5 mL | 24.99 mL | 49.97 mL |
| 5 mM | 1 mL | 5 mL | 9.99 mL |
| 10 mM | 0.5 mL | 2.5 mL | 5 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for OR-486
References for OR-486
References are publications that support the biological activity of the product.
Mannisto and Kaakola (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 66 317 PMID: 2196554
Borgulya et al (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta 72 952
If you know of a relevant reference for OR-486, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: OR-486, OR-486 supplier, Catechol, O-methyl, transferase, COMT, inhibitors, inhibits, Adrenergic, Related, Compounds, Dopaminergic-Related, O-Methyltransferase, 0483, Tocris Bioscience
2 Citations for OR-486
Citations are publications that use Tocris products. Selected citations for OR-486 include:
Oróstica et al (2014) OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction 148 285 PMID: 25038866
Ciszek et al (2016) Persistent catechol-O-methyltransferase-dependent pain is initiated by peripheral β-andrenergic receptors. Anesthesiology 124 1122 PMID: 26950706
Do you know of a great paper that uses OR-486 from Tocris? Please let us know.
Reviews for OR-486
There are currently no reviews for this product. Be the first to review OR-486 and earn rewards!
Have you used OR-486?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.