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Submit ReviewOrg 12962 hydrochloride
Description: Selective 5-HT2C agonist
Chemical Name: 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Org 12962 hydrochloride
Selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.
Technical Data for Org 12962 hydrochloride
| M. Wt | 302.12 |
| Formula | C10H11ClF3N3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 210821-63-9 |
| PubChem ID | 9796407 |
| InChI Key | FVDILXYXZAAJOS-UHFFFAOYSA-N |
| Smiles | ClC1=NC(N2CCNCC2)=CC=C1C(F)(F)F.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Org 12962 hydrochloride
References for Org 12962 hydrochloride
References are publications that support the biological activity of the product.
Jenck et al (1998) Antiaversive effects of 5-HT2C receptor agonists and fluox. in a model of panic-like anxiety in rats. Eur.Neuropsychopharmacol. 8 161 PMID: 9716307
Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829
Halford et al (2005) Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr.Drug Targets 6 201 PMID: 15777190
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.