Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewOUL 35
Description: Selective PARP-10 inhibitor
Chemical Name: 4,4'-Oxybis[benzamide]
Purity: ≥98% (HPLC)
Biological Activity for OUL 35
OUL 35 is a selective PARP-10 (also known as ADP-ribosyltransferase Diptheria Toxin-like 10, ARTD10) inhibitor (IC50 = 0.329 μM). Displays selectivity for PARP-10 over a panel of PARP family members. Rescues HeLa cells from PARP-10-induced cell death. Sensitizes cancer cells to hydroxyurea-induced genotoxic stress.
Compound Libraries for OUL 35
OUL 35 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for OUL 35
| M. Wt | 256.26 |
| Formula | C14H12N2O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 6336-34-1 |
| PubChem ID | 236501 |
| InChI Key | XZRCQWLPMXFGHE-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=C(C=C1)OC2=CC=C(C(N)=O)C=C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OUL 35
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.63 | 100 |
Preparing Stock Solutions for OUL 35
The following data is based on the product molecular weight 256.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.9 mL | 19.51 mL | 39.02 mL |
| 5 mM | 0.78 mL | 3.9 mL | 7.8 mL |
| 10 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for OUL 35
References for OUL 35
References are publications that support the biological activity of the product.
Venkannagari et al (2016) Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem.Biol. 23 1251 PMID: 27667561
If you know of a relevant reference for OUL 35, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: OUL 35, OUL 35 supplier, OUL35, PARP10, ARTD10, inhibitors, inhibits, ADP-ribosyltransferase, Diptheria, Toxin-like, 10, Poly, (ADP-ribose), polymerase, Poly(ADP-ribose), Polymerase, 6344, Tocris Bioscience
Citations for OUL 35
Citations are publications that use Tocris products.
Currently there are no citations for OUL 35. Do you know of a great paper that uses OUL 35 from Tocris? Please let us know.
Reviews for OUL 35
There are currently no reviews for this product. Be the first to review OUL 35 and earn rewards!
Have you used OUL 35?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.