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Submit ReviewOXA (17-33)
Description: Potent and selective peptide OX1 agonist
Purity: ≥95% (HPLC)
Biological Activity for OXA (17-33)
OXA (17-33) is a potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A (Cat. No. 1455).
Technical Data for OXA (17-33)
| M. Wt | 1749 |
| Formula | C79H125N23O22 |
| Sequence |
YELLHGAGNHAAGILTL (Modifications: Leu-33 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 343268-91-7 |
| PubChem ID | 44376806 |
| InChI Key | JPRBZUXULYLVPJ-HYNYKCRDSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OXA (17-33)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for OXA (17-33)
References for OXA (17-33)
References are publications that support the biological activity of the product.
Darker et al (2001) Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor. Bioorg.Med.Chem.Lett. 11 737 PMID: 11266181
German et al (2013) Truncated orexin peptides: structure-activity relationship studies. Med.Chem.Lett. 4 1224 PMID: 24707347
If you know of a relevant reference for OXA (17-33), please let us know.
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Keywords: OXA (17-33), OXA (17-33) supplier, Potent, selective, orexin, OX1, receptors, agonists, Receptor, 5115, Tocris Bioscience
3 Citations for OXA (17-33)
Citations are publications that use Tocris products. Selected citations for OXA (17-33) include:
Feng et al (2012) Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain. Drug Des Devel Ther 12 225 PMID: 23173601
Kelsey et al (2022) Properties and modulation of excitatory inputs to the locus coeruleus. J Physiol 600 4897-4916 PMID: 36156249
Hugh D et al (2014) Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock. J Neurosci 34 3607-21 PMID: 24599460
Do you know of a great paper that uses OXA (17-33) from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.