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Submit Reviewp-Chlorophenylalanine
Description: Tryptophan hydroxylase inhibitor
Purity: ≥99% (HPLC)
Biological Activity for p-Chlorophenylalanine
p-Chlorophenylalanine is a binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.
Technical Data for p-Chlorophenylalanine
| M. Wt | 199.64 |
| Formula | C9H10ClNO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 7424-00-2 |
| PubChem ID | 4652 |
| InChI Key | NIGWMJHCCYYCSF-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)CC1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for p-Chlorophenylalanine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 10 |
Preparing Stock Solutions for p-Chlorophenylalanine
The following data is based on the product molecular weight 199.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 50.09 mL | 250.45 mL | 500.9 mL |
| 0.5 mM | 10.02 mL | 50.09 mL | 100.18 mL |
| 1 mM | 5.01 mL | 25.05 mL | 50.09 mL |
| 5 mM | 1 mL | 5.01 mL | 10.02 mL |
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Product Datasheets for p-Chlorophenylalanine
References for p-Chlorophenylalanine
References are publications that support the biological activity of the product.
Datla and Curzon (1996) Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 35 315 PMID: 8783206
Koyuncuoglu et al (1975) The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat. Psychopharmacologia 45 163 PMID: 129787
If you know of a relevant reference for p-Chlorophenylalanine, please let us know.
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Keywords: p-Chlorophenylalanine, p-Chlorophenylalanine supplier, Tryptophan, hydroxylases, inhibitors, inhibits, serotonin, depletion, PCPA, fenclonine, 5-HT-Related, Hydroxylases, 5-HT3, Receptors, 0938, Tocris Bioscience
2 Citations for p-Chlorophenylalanine
Citations are publications that use Tocris products. Selected citations for p-Chlorophenylalanine include:
Tullius et al (2014) NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun 5 5101 PMID: 25290058
Hernandez et al (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Proc Natl Acad Sci U S A 302 E1009 PMID: 22318950
Do you know of a great paper that uses p-Chlorophenylalanine from Tocris? Please let us know.
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