Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewP7C3
Description: NAMPT activator; also proneurogenic and neuroprotective
Chemical Name: 3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
Purity: ≥99% (HPLC)
Biological Activity for P7C3
P7C3 is a NAMPT activator. Proneurogenic and neuroprotective. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. Orally available and brain penetrant. Also revents doxorubicin-mediated toxicity in osteosarcoma cells and restores intracellular NAD levels.
Compound Libraries for P7C3
P7C3 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for P7C3
| M. Wt | 474.19 |
| Formula | C21H18Br2N2O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 301353-96-8 |
| PubChem ID | 2836187 |
| InChI Key | FZHHRERIIVOATI-UHFFFAOYSA-N |
| Smiles | BrC(C=C3)=CC1=C3N(CC(O)CNC4=CC=CC=C4)C2=C1C=C(Br)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for P7C3
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.42 | 100 |
Preparing Stock Solutions for P7C3
The following data is based on the product molecular weight 474.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.11 mL | 10.54 mL | 21.09 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.11 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for P7C3
References for P7C3
References are publications that support the biological activity of the product.
Pieper et al (2010) Discovery of a proneurogenic, neuroprotective chemical. Cell 142 39 PMID: 20603013
Wang et al (2014) P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158 1324 PMID: 25215490
If you know of a relevant reference for P7C3, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: P7C3, P7C3 supplier, P7C3, neuroprotective, neurogenesis, proneurogenic, NAMPT, Neural, Stem, Cells, 4076, Tocris Bioscience
Citations for P7C3
Citations are publications that use Tocris products.
Currently there are no citations for P7C3. Do you know of a great paper that uses P7C3 from Tocris? Please let us know.
Reviews for P7C3
There are currently no reviews for this product. Be the first to review P7C3 and earn rewards!
Have you used P7C3?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.