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Submit ReviewPA Janelia Fluor® 646, Haloalkane New
Description: Photoactivatable Janelia Fluor® 646 with chloroalkane handle for self-labeling tags fusion protein
Chemical Name: 2',7'-Bis(1-azetidinyl)-2-diazo-N-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethyl]-2,3-dihydro-9',9'-dimethyl-3-oxospiro[1H-indene-1,10'(9'H)-[9]silaanthracene]-6-carboxamide
Purity: ≥95% (HPLC)
Biological Activity for PA Janelia Fluor® 646, Haloalkane
Key Information: PA Janelia Fluor® 646, Haloalkane is a red cell-permeable photoactivable fluorescent dye with a chloroalkane handle for labeling fusion tag proteins.
Application: Live-cell imaging as a self-labeling tag substrate. Suitable for confocal microscopy, super-resolution microscopy (SRM) techniques including PALM (in both live and fixed cells). Allows multicolor single tracking experiments.
Properties and Photophysical Data: PA Janelia Fluor® 646, Haloalkane shows superior brightness and photostability.
Janelia Fluor is a registered trademark of Howard Hughes Medical Institute.
Licensing Information
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus
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Technical Data for PA Janelia Fluor® 646, Haloalkane
| M. Wt | 726.39 |
| Formula | C40H48ClN5O4Si |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2011720-21-9 |
| PubChem ID | 141653447 |
| InChI Key | MOVPVSNYWBCKNC-UHFFFAOYSA-N |
| Smiles | ClCCCCCCOCCOCCNC(C1=CC=C(C(C2=[N+]=[N-])=O)C(C32C4=CC=C(N5CCC5)C=C4[Si](C)(C)C6=CC(N7CCC7)=CC=C36)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PA Janelia Fluor® 646, Haloalkane
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.26 | 10 |
Preparing Stock Solutions for PA Janelia Fluor® 646, Haloalkane
The following data is based on the product molecular weight 726.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.77 mL | 68.83 mL | 137.67 mL |
| 0.5 mM | 2.75 mL | 13.77 mL | 27.53 mL |
| 1 mM | 1.38 mL | 6.88 mL | 13.77 mL |
| 5 mM | 0.28 mL | 1.38 mL | 2.75 mL |
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Product Datasheets for PA Janelia Fluor® 646, Haloalkane
References for PA Janelia Fluor® 646, Haloalkane
References are publications that support the biological activity of the product.
Grimm et al (2016) Bright photoactivatable fluorophores for single-molecule imaging Nat.Methods 13 985 PMID: 27776112
If you know of a relevant reference for PA Janelia Fluor® 646, Haloalkane, please let us know.
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