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Submit ReviewPAF (C16)
Description: Endogenous platelet-activating factor (PAF)
Alternative Names: Platelet-activating factor
Chemical Name: (7R)-7-(Acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium-4-oxide
Biological Activity for PAF (C16)
PAF (C16) is an endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.
Technical Data for PAF (C16)
| M. Wt | 523.68 |
| Formula | C26H54NO7P |
| Storage | Store at -20°C |
| CAS Number | 74389-68-7 |
| PubChem ID | 108156 |
| InChI Key | HVAUUPRFYPCOCA-AREMUKBSSA-N |
| Smiles | CC(O[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PAF (C16)
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 52.37 | 100 |
Preparing Stock Solutions for PAF (C16)
The following data is based on the product molecular weight 523.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.55 mL | 19.1 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets for PAF (C16)
References for PAF (C16)
References are publications that support the biological activity of the product.
Oda et al (1985) Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. J.Immunol. 134 1090 PMID: 3917470
Archer et al (1988) Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man. J.Invest.Dermatol. 91 82 PMID: 3385217
Handa et al (1991) Vasorelaxant effect of C16-PAF and C18-PAF on renal blood flow and systemic blood pressure in the anesthetized rat. Life Sci. 49 747 PMID: 1875784
If you know of a relevant reference for PAF (C16), please let us know.
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Keywords: PAF (C16), PAF (C16) supplier, Endogenous, platelet-activating, factor, PAF, Receptors, Platelet-activating, Factor, (PAF), 2940, Tocris Bioscience
Citations for PAF (C16)
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Reviews for PAF (C16)
Average Rating: 5 (Based on 1 Review.)
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Platelet activating factor (PAF).
By
Anonymous on 05/02/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: microglia
Platelet activating factor (PAF) at 100nM induced a biphasic calcium response in microglia culture. Initial release from internal source and subsequent a sustained influx.