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PAG 4'-piperazine-4-methylpiperidine

Cat. No. 7999 Submit a Review Datasheet / COA / SDS
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Description: Cereblon ligand with terminal piperidine for onward chemistry
Chemical Name: 3-[[4-[4-(Piperidin-4-ylmethyl)piperazin-1-yl]phenyl]amino]piperidine-2,6-dione trihydrochloride
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity

Phenyl amino glutarimide (PAG) 4'-piperazine-4-methylpiperidine is a functionalized cereblon ligand for PROTAC® research and development. Incorporates an E3 ligase ligand with a terminal piperidine for onward chemistry to generate Protein Degraders with rigid linkers. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M. Wt 494.89
Formula C21H31N5O2.3HCl
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 3055107-65-5
InChI Key KQGPUFWXYCIAOJ-UHFFFAOYSA-N
Smiles O=C(N1)C(NC2=CC=C(C=C2)N3CCN(CC3)CC4CCNCC4)CCC1=O.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

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Citations for PAG 4'-piperazine-4-methylpiperidine

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia