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Submit ReviewPam2CSK4
Description: TLR2/6 agonist; induces TNF-α production
Purity: ≥95% (HPLC)
Biological Activity for Pam2CSK4
Pam2CSK4 is a toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.
Technical Data for Pam2CSK4
| M. Wt | 1271.83 |
| Formula | C65H126N10O12S |
| Sequence |
CSKKKK (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 868247-72-7 |
| PubChem ID | 71457280 |
| InChI Key | LJUIOEFZFQRWJG-GHYFRYPYSA-N |
| Smiles | [H]N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pam2CSK4
| Solubility | Soluble to 1 mg/ml in 0.25% acetic acid |
Product Datasheets for Pam2CSK4
References for Pam2CSK4
References are publications that support the biological activity of the product.
Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6 e25542 PMID: 21991317
Omueti et al (2005) Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 280 36616 PMID: 16129684
Schromm et al (2007) Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 282 11030 PMID: 17308304
If you know of a relevant reference for Pam2CSK4, please let us know.
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Keywords: Pam2CSK4, Pam2CSK4 supplier, TLR2, TLR6, agonists, Toll-like, receptors, induces, inducers, TNF-a, TNF-alpha, TNF-α, tumor, tumour, necrosis, factor, production, Receptors, 4637, Tocris Bioscience
3 Citations for Pam2CSK4
Citations are publications that use Tocris products. Selected citations for Pam2CSK4 include:
Alexa et al (2023) Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells. Heliyon 9 e15202 PMID: 37123974
Hari et al (2019) The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv 5 eaaw0254 PMID: 31183403
Valerie G et al (2022) Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. Cell Death Differ 29 1267-1282 PMID: 34916628
Do you know of a great paper that uses Pam2CSK4 from Tocris? Please let us know.
Reviews for Pam2CSK4
Average Rating: 5 (Based on 1 Review.)
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Pam2CSK4 induces TNFa production and release.
By
Anonymous on 12/12/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Macrophages
Raw macrophages were stimulated either with LPS (200 ng/ml) or Pam2CSK4 (50 nM) for 8 h to follow TNFa concentration in cell culture medium using ELISA. Pam2CSK4 induced TNFa production and release in a similar extent as LPS.
Pathways for Pam2CSK4
