Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPamoic acid disodium salt
Description: GPR35 agonist
Chemical Name: 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic acid) disodium salt
Purity: ≥99% (HPLC)
Biological Activity for Pamoic acid disodium salt
Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.
Technical Data for Pamoic acid disodium salt
| M. Wt | 432.33 |
| Formula | C23H14Na2O6 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 6640-22-8 |
| PubChem ID | 2723841 |
| InChI Key | YGLLICRFEVEWOZ-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].OC1=C(CC2=C3C=CC=CC3=CC(C([O-])=O)=C2O)C2=CC=CC=C2C=C1C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pamoic acid disodium salt
References for Pamoic acid disodium salt
References are publications that support the biological activity of the product.
Zhao et al (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 78 560 PMID: 20826425
Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683 PMID: 22967846
View Related Products by Target
View Related Products by Product Action
Keywords: Pamoic acid disodium salt, Pamoic acid disodium salt supplier, gpr35, orphan, gpcr, agonists, GPR35, 4298, Tocris Bioscience
Citations for Pamoic acid disodium salt
Citations are publications that use Tocris products.
Currently there are no citations for Pamoic acid disodium salt.
Reviews for Pamoic acid disodium salt
There are currently no reviews for this product. Be the first to review Pamoic acid disodium salt and earn rewards!
Have you used Pamoic acid disodium salt?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image