Home / Pharmacology / GPCRs / 7-TM Receptors / Peptide Receptors / Mas-Related G Protein-Coupled Receptors / Mas-Related G Protein-Coupled Receptors Agonists / PAMP-20 (human)

PAMP-20 (human)

Cat. No. 6552 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: MRGPRX2 agonist; also non-competitive nAChR antagonist
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PAMP-20 (human)

PAMP-20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.

Technical Data for PAMP-20 (human)

M. Wt 2460.87
Formula C112H178N36O27
Sequence ARLDVASEFRKKWNKWALSR

(Modifications: Arg-20 = C-terminal amide)
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 150238-87-2
PubChem ID 71311703
InChI Key PIRWNASAJNPKHT-SHZATDIYSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PAMP-20 (human)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for PAMP-20 (human)

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for PAMP-20 (human)

References are publications that support the biological activity of the product.

Mahata et al (1998) Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension 32 907 PMID: 9822452

Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun, 330 1146 PMID: 15823563

If you know of a relevant reference for PAMP-20 (human), please let us know.

View Related Products by Target

View Related Products by Product Action

View all Mas-Related G Protein-Coupled Receptors Agonists

Keywords: PAMP-20 (human), PAMP-20 (human) supplier, PAMP, n-terminal, 1-20, human, proadrenomedullin, ProAM, N20, Mas, related, GPR, X2, MRGPRX2, agonists, agonism, Mas-related, G, Protein-Coupled, Receptors, Nicotinic, (Non-selective), 6552, Tocris Bioscience

Citations for PAMP-20 (human)

Citations are publications that use Tocris products.

Currently there are no citations for PAMP-20 (human). Do you know of a great paper that uses PAMP-20 (human) from Tocris? Please let us know.

Reviews for PAMP-20 (human)

There are currently no reviews for this product. Be the first to review PAMP-20 (human) and earn rewards!

Have you used PAMP-20 (human)?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review