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Submit ReviewpCPA methyl ester hydrochloride
Description: Tryptophan hydroxylase inhibitor
Chemical Name: 4-Chloro-DL-Phenylalanine methyl ester hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for pCPA methyl ester hydrochloride
pCPA methyl ester hydrochloride is a tryptophan hydroxylase inhibitor. Inhibits 5-HT synthesis. Depletes 5-HT levels in orbitofrontal cortex and impairs reversal learning in rats. Methyl ester of p-Chlorophenylalanine (Cat. No. 0938).
Compound Libraries for pCPA methyl ester hydrochloride
pCPA methyl ester hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for pCPA methyl ester hydrochloride
| M. Wt | 250.12 |
| Formula | C10H12ClNO2.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 14173-40-1 |
| PubChem ID | 26531 |
| InChI Key | GCBCWTWQAFLKJG-UHFFFAOYSA-N |
| Smiles | O=C(C(CC1=CC=C(C=C1)Cl)N)OC.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for pCPA methyl ester hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.01 | 100 | |
| DMSO | 25.01 | 100 |
Preparing Stock Solutions for pCPA methyl ester hydrochloride
The following data is based on the product molecular weight 250.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4 mL | 19.99 mL | 39.98 mL |
| 5 mM | 0.8 mL | 4 mL | 8 mL |
| 10 mM | 0.4 mL | 2 mL | 4 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
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Product Datasheets for pCPA methyl ester hydrochloride
References for pCPA methyl ester hydrochloride
References are publications that support the biological activity of the product.
Pinto Brod et al (2016) Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test. Prog.Neuropsychopharmacol.Biol.Psychiatry. 65 201 PMID: 26596986
Wallace et al (2014) Vort. restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. Int.J.Neuropsychopharmacol. 17 1695 PMID: 24852131
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