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Submit ReviewPD 161570
Description: Selective FGFR inhibitor
Chemical Name: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Purity: ≥97% (HPLC)
Biological Activity for PD 161570
PD 161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for PD 161570
PD 161570 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for PD 161570
| M. Wt | 532.51 |
| Formula | C26H35Cl2N7O |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 192705-80-9 |
| PubChem ID | 5328135 |
| InChI Key | MKVMEJKNLUWFSQ-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CC(Cl)=C1C3=CC2=CN=C(NCCCCN(CC)CC)N=C2N=C3NC(NC(C)(C)C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PD 161570
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.25 | 100 | |
| ethanol | 53.25 | 100 |
Preparing Stock Solutions for PD 161570
The following data is based on the product molecular weight 532.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.88 mL | 9.39 mL | 18.78 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.88 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets for PD 161570
References for PD 161570
References are publications that support the biological activity of the product.
Hamby et al (1997) Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J.Med.Chem. 40 2296 PMID: 9240345
Batley et al (1998) Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor. Life Sci. 62 143 PMID: 9488112
Stevens et al (2003) Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol.Endocrinology 17 1751 PMID: 12805413
If you know of a relevant reference for PD 161570, please let us know.
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Keywords: PD 161570, PD 161570 supplier, PD161570, selective, FGFR, inhibitors, inhibits, fibroblast, growth, factors, Pfizer, 3724, Tocris Bioscience
3 Citations for PD 161570
Citations are publications that use Tocris products. Selected citations for PD 161570 include:
Tomohiro et al (2020) Regulation of NF-kB Signalling Through the PR55β-RelA Interaction in Osteoblasts. In Vivo 34 601-608 PMID: 32111759
Magaña et al (2014) Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation. Dev Biol 387 15 PMID: 24445281
Rodríguez et al (2012) Modulation of pluripotency in the porcine embryo and iPS cells. J Exp Bot 7 e49079 PMID: 23145076
Do you know of a great paper that uses PD 161570 from Tocris? Please let us know.
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