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PDEδ ATTEC 12C

Cat. No. 8824 Submit a Review Datasheet / COA / SDS
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Description: PDEδ autophagy-tethering compound (ATTEC) Degrader
Chemical Name: N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PDEδ ATTEC 12C

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC50 = 1.7 μM; Dmax = 85%; Kd = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC50 values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.

Technical Data for PDEδ ATTEC 12C

M. Wt 999.54
Formula C41H42Br2IN7O5
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key BYPQUTISFKWFMK-DXJNIWACSA-N
Smiles BrC1=CC(/C=C2C(C=C(I)C=C3)=C3NC/2=O)=CC(Br)=C1OCC(NCCCCCCNC(CCCN4C(C5=NN(C6=CC=C(C)C=C6)C(C)=C5C(C)=N4)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PDEδ ATTEC 12C

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.99 20

Preparing Stock Solutions for PDEδ ATTEC 12C

The following data is based on the product molecular weight 999.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 5 mL 25.01 mL 50.02 mL
1 mM 1 mL 5 mL 10 mL
2 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.1 mL 0.5 mL 1 mL

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Product Datasheets for PDEδ ATTEC 12C

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for PDEδ ATTEC 12C

References are publications that support the biological activity of the product.

Bao et al (2024) Discovery of novel PDEδ autophagic degraders: a case study of autophagy-tethering compound (ATTEC). ACS Med.Chem.Lett. 15 29 PMID: 38229750

If you know of a relevant reference for PDEδ ATTEC 12C, please let us know.

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Citations for PDEδ ATTEC 12C

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia