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Submit ReviewPF 04885614
Description: Potent and selective NaV1.8 channel blocker; active in vivo
Chemical Name: 1-Methyl-1-[4-(4-trifluoromethoxy-phenyl)-1H-imidazol-2-yl]-ethylamine
Purity: ≥98% (HPLC)
Biological Activity for PF 04885614
PF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for PF 04885614
PF 04885614 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PF 04885614
| M. Wt | 285.26 |
| Formula | C13H14F3N3O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1480833-70-2 |
| PubChem ID | 65459349 |
| InChI Key | AGORGFNWYAUYSU-UHFFFAOYSA-N |
| Smiles | CC(C)(N)C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PF 04885614
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.53 | 100 | |
| ethanol | 28.53 | 100 |
Preparing Stock Solutions for PF 04885614
The following data is based on the product molecular weight 285.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.51 mL | 17.53 mL | 35.06 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.01 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.51 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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Product Datasheets for PF 04885614
References for PF 04885614
References are publications that support the biological activity of the product.
Bagal et al (2013) Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract. 4th RSC/SCI Symp. on Ion Channels as Ther. Targ
If you know of a relevant reference for PF 04885614, please let us know.
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Citations for PF 04885614
Citations are publications that use Tocris products.
Currently there are no citations for PF 04885614. Do you know of a great paper that uses PF 04885614 from Tocris? Please let us know.
Reviews for PF 04885614
Average Rating: 5 (Based on 1 Review.)
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PF 04885614 used to understand the modulation of peripheral sensitisation.
By
Alex Samuel on 01/16/2020
Species: Human
PF 04885614 as an inhibitor was used to understand the modulation of peripheral sensitisation.
