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Submit ReviewPF 5081090
Description: Potent LpxC inhibitor
Chemical Name: (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide
Purity: ≥98% (HPLC)
Biological Activity for PF 5081090
Potent antibacterial agent which disrupts lipid bilayer synthesis through inhibition of LpxC (IC50 = 1.1 nM in Pseudomonas aeruginosa); effective against a range of gram negative bacteria.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 5081090
| M. Wt | 412.43 |
| Formula | C18H21FN2O6S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1312473-63-4 |
| PubChem ID | 56964907 |
| InChI Key | DNVUWHWBCMGQLU-GOSISDBHSA-N |
| Smiles | O=C1N(CC[C@]([S@@](C)(=O)=O)(C)C(NO)=O)C=CC(C2=CC=C(OC)C=C2F)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 5081090
References for PF 5081090
References are publications that support the biological activity of the product.
Montgomery et al (2012) Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections. J.Med.Chem. 55 1662 PMID: 22257165
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