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Submit ReviewPF 6274484
Description: High affinity and potent covalent EGFR kinase inhibitor
Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
Purity: ≥98% (HPLC)
Biological Activity for PF 6274484
PF 6274484 is a high affinity and potent covalent EGFR kinase inhibitor (Ki = 0.14 nM). Inhibits autophosphorylation of WT and mutant EGFR in tumor cells (IC50 values are 5.8 and 6.6 nM, respectively).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 6274484
| M. Wt | 372.78 |
| Formula | C18H14ClFN4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1035638-91-5 |
| PubChem ID | 74766099 |
| InChI Key | TUYDDIWQXWTNSW-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)C=C1NC(C=C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 6274484
References for PF 6274484
References are publications that support the biological activity of the product.
Schwartz et al (2014) Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance. Proc.Natl.Acad.Sci.U.S.A. 111 173 PMID: 24347635
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Keywords: PF 6274484, PF 6274484 supplier, PF6274484, epidermal, growth, factor, receptors, EGFR, kinase, inhibitors, inhibits, potent, high, affinity, covalent, 5939, Tocris Bioscience
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