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Submit ReviewPG 931
Description: Potent and selective MC4 receptor agonist
Biological Activity for PG 931
PG 931 is a potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.
Technical Data for PG 931
| M. Wt | 1180.41 |
| Formula | C59H85N15O11 |
| Sequence |
XDPFRWKPV (Modifications: X-1 = Ac-Nle, Phe-4 = D-Phe, Val-9 = C-terminal amide, Asp-2, Lys-7, Cyclized) |
| Storage | Store at -20°C |
| CAS Number | 667430-81-1 |
| PubChem ID | 90489007 |
| InChI Key | WOFDJLFPEWSAPJ-RVBGBMFGSA-N |
| Smiles | CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H]2CCCN2C1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PG 931
References for PG 931
References are publications that support the biological activity of the product.
Giuliani et al (2007) Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br.J.Pharmacol. 150 595 PMID: 17245369
Grieco et al (2003) Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J.Pept.Res. 62 199 PMID: 14531843
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Keywords: PG 931, PG 931 supplier, PG931, Potent, selective, MC4R, receptors, agonists, Melanocortin, Receptors, 5094, Tocris Bioscience
Citations for PG 931
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Currently there are no citations for PG 931.
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.