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Submit ReviewPhalloidin
Description: Promotes actin polymerization
Purity: ≥90% (HPLC)
Biological Activity for Phalloidin
Phalloidin is a promotes actin polymerization. Decreases dissociation rate constant for actin subunits from filament ends; lowers critical concentration for polymerization.
Technical Data for Phalloidin
| M. Wt | 788.87 |
| Formula | C35H48N8O11S |
| Sequence | ATCXAWL (Modifications: Cyclic Cys-3-Trp-6, X=Hyp, D-Thr-2) |
| Storage | Store at -20°C |
| Purity | ≥90% (HPLC) |
| CAS Number | 17466-45-4 |
| PubChem ID | 90488951 |
| InChI Key | KPKZJLCSROULON-RCGKFKHASA-N |
| Smiles | O=C([C@H](N5)CSC(NC3=C2C=CC=C3)=C2C[C@@H](C(N[C@@H](C[C@](O)(C)CO)C(NC(C(N[C@H]([C@H](C)O)C5=O)=O)C)=O)=O)NC([C@@H](N[C@]4=O)C)=O)N1[C@H]4C[C@@H](O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Phalloidin
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Phalloidin
References for Phalloidin
References are publications that support the biological activity of the product.
Diensthuber et al (2011) Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin. FEBS Lett. 585 767 PMID: 21295570
Cooper (1987) Effects of cytochalasin and phalloidin on actin. J.Cell Biol. 105 1473 PMID: 3312229
Coluccio and Tilney (1984) Phalloidin enhances actin assembly by preventing monomer dissociation. J.Cell Biol. 99 529 PMID: 6746738
Wehland et al (1977) Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. Proc.Natl.Acad.Sci.USA 74 5613 PMID: 341163
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Keywords: Phalloidin, Phalloidin supplier, actin, polymerization, polymerisation, promoters, Actin, 4535, Tocris Bioscience
1 Citation for Phalloidin
Citations are publications that use Tocris products. Selected citations for Phalloidin include:
Zhen et al (2009) Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex. J Neurosci 29 550-62 PMID: 19144855
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