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Submit Review[Phe8Ψ(CH-NH)-Arg9]-Bradykinin
Description: Selective B2 agonist
Purity: ≥95% (HPLC)
Biological Activity for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
[Phe8Ψ(CH-NH)-Arg9]-Bradykinin is a selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin (Cat No. 3004) in vivo.
Technical Data for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
| M. Wt | 1046.23 |
| Formula | C50H75N15O10 |
| Sequence |
RPPGFSPFR (Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH2-NH)) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 118122-39-7 |
| PubChem ID | 3082903 |
| InChI Key | XKJBISGEHGXKBF-TZPCGENMSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CN[C@@H](CCCNC(N)=N)C(O)=O)CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
References for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
References are publications that support the biological activity of the product.
Drapeau et al (1988) [Phe8Ψ(CH2-NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down by either kininase I or kininase II. Eur.J.Pharmacol. 155 193 PMID: 2907489
Marceau et al (2002) Kinin receptors: functional aspects. Int.Immunopharmacol. 2 1729 PMID: 12489786
Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727
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Keywords: [Phe8Y(CH-NH)Arg9]-Bradykinin, [Phe8Y(CH-NH)Arg9]-Bradykinin supplier, Selective, B2, agonists, Bradykinin, Receptors, [Phe8psi(CH-NH)Arg9]-Bradykinin, 3229, Tocris Bioscience
1 Citation for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
Citations are publications that use Tocris products. Selected citations for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin include:
Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324
Reviews for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
Average Rating: 5 (Based on 1 Review.)
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Does what it is meant to.
By
Anonymous on 05/13/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: neurons
20 nM bradykinin
