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Phenamil

Cat. No. 3379 Submit a Review Datasheet / COA / SDS
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Description: Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels
Chemical Name: 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
Purity: ≥99% (HPLC)
Datasheet
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Phenamil

Phenamil is a TRPP3 channel inhibitor (IC50 = 0.14 μM). Also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Derivative of amiloride (Cat. No. 0890).

Compound Libraries for Phenamil

Phenamil is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Phenamil

M. Wt 401.83
Formula C12H12ClN7O.CH3SO3H
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1161-94-0
PubChem ID 9604979
InChI Key MHPIZTURFVSLTJ-UHFFFAOYSA-N
Smiles NC1=C(Cl)N=C(C(NC(NC2=CC=CC=C2)=N)=O)C(N)=N1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Phenamil

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.18 100

Preparing Stock Solutions for Phenamil

The following data is based on the product molecular weight 401.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Phenamil

References are publications that support the biological activity of the product.

Barbry et al (1989) Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels. Biochemistry. 28 3744 PMID: 2546581

Dai et al (2007) Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601

If you know of a relevant reference for Phenamil, please let us know.

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Keywords: Phenamil, Phenamil supplier, TRPP3, TRP, antagonists, sodium, channels, blocker, amiloride, Na, epithelial, Epithelial, Sodium, Channels, TRPP, 3379, Tocris Bioscience

Citations for Phenamil

Citations are publications that use Tocris products.

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