TRPP Channels

The polycystin transient receptor potential (TRPP) channels are a subfamily of TRP channels that, when mutated, can lead to polycystic kidney disease. The TRPP channels are divided into two structurally distinct groups, polycystic kidney disease 1-like (PKD1-like) and polycystic kidney disease 2-like (PKD2-like). Members of the PKD1-like group in mammals include PKD1 (reclassified as TRPP1), PDKREJ, PKD1L1, PKD1L2 and PKD1L3. The PKD2-like members include PKD2; PKD2L1; and PKD2L2, which have renamed TRPP2; TRPP3; and TRPP5 respectively.

TRPP1 contains 11 putative transmembrane domains and an extremely large and complex extracellular N-terminal domain. It has also been suggested that TRPP1 and TRPP2 can physically couple to act as a signaling complex, yet TRPP1 appears to be incapable of producing currents so may not form a functional channel. In contrast, TRPP2 is suggested to be important for cilia movement, development of the heart, skeletal muscle and kidney. TRPP3 plays a role in retinal development, whilst there is limited functional data for TRPP4 and -5.

External sources of pharmacological information for TRPP Channels :

• IUPHAR Receptor Code

• BJP Guide

TRPP Gene Data