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Submit ReviewPhlorizin
Description: Na+-glucose cotransporter (SGLT) inhibitor
Chemical Name: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
Purity: ≥99% (HPLC)
Biological Activity for Phlorizin
Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.
Technical Data for Phlorizin
| M. Wt | 436.41 |
| Formula | C21H24O10 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 60-81-1 |
| PubChem ID | 6072 |
| InChI Key | IOUVKUPGCMBWBT-QNDFHXLGSA-N |
| Smiles | O=C(CCC2=CC=C(O)C=C2)C1=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Phlorizin
References for Phlorizin
References are publications that support the biological activity of the product.
Rossetti et al (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to Ins in diabetic rats. J.Clin.Invest. 79 1510 PMID: 3571496
Ehrenkranz et al (2005) Phlorizin: a review. Diabetes Metab Res Rev. 21 31 PMID: 15624123
Wright (2001) Renal Na+-glucose cotransporters. Am.J.Physiol.Renal.Physiol. 280 F10 PMID: 11133510
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Keywords: Phlorizin, Phlorizin supplier, sodium, glucose, cotransporters, SGLT1, SGLT2, glycosuria, hyperglycemia, inhibitors, inhibits, Other, Ion, Pumps/Transporters, 4627, Tocris Bioscience
1 Citation for Phlorizin
Citations are publications that use Tocris products. Selected citations for Phlorizin include:
Smith et al (2018) T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways. Mol Metab 17 98 PMID: 30201274
Reviews for Phlorizin
Average Rating: 5 (Based on 1 Review.)
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Phlorizin inhibits LPS-induced iNOS in HL-1 cells.
By
Chintan Koyani on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: cardiomyocytes
HL-1 cardiomyocytes were stimulated with Phlorizin (0-200 µM) alone or in combination with LPS (1 µg/ml) for 8 h to follow iNOS expression by Western blot. Phlorizin inhibited LPS-induced iNOS expression starting from 100 µM concentration (shown in Image).
