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Submit ReviewPioglitazone hydrochloride
Description: Selective PPARγ agonist; antidiabetic agent
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Pioglitazone hydrochloride
Pioglitazone hydrochloride is a selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity. Also enhances proliferation and survival of mESCs and acts synergistically with Y-27632 (Cat. No. 1254) to improve survival of dissociated single hPSCs and increase colony formation.
Compound Libraries for Pioglitazone hydrochloride
Pioglitazone hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for Pioglitazone hydrochloride
| M. Wt | 392.9 |
| Formula | C19H20N2O3S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 112529-15-4 |
| PubChem ID | 60560 |
| InChI Key | GHUUBYQTCDQWRA-UHFFFAOYSA-N |
| Smiles | O=C(S3)NC(C3CC(C=C2)=CC=C2OCCC1=NC=C(CC)C=C1)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pioglitazone hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.82 | 25 |
Preparing Stock Solutions for Pioglitazone hydrochloride
The following data is based on the product molecular weight 392.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.18 mL | 50.9 mL | 101.81 mL |
| 1.25 mM | 2.04 mL | 10.18 mL | 20.36 mL |
| 2.5 mM | 1.02 mL | 5.09 mL | 10.18 mL |
| 12.5 mM | 0.2 mL | 1.02 mL | 2.04 mL |
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Product Datasheets for Pioglitazone hydrochloride
References for Pioglitazone hydrochloride
References are publications that support the biological activity of the product.
Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907
Sakamoto et al (2000) Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglit. Biochem.Biophys.Res.Commun. 278 704 PMID: 11095972
Momose et al (2002) Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as Ins sensitizers with antidiabetic activities. J.Med.Chem. 45 1518 PMID: 11906293
Kajabadi et al (2015) The synergistic enhancement of cloning efficiency in individualized human pluripotent stem cells by peroxisome proliferative-activated receptor-γ (PPARγ) activation and Rho-associated kinase (ROCK) inhibition. J.Biol.Chem. 290 26303 PMID: 26336103
If you know of a relevant reference for Pioglitazone hydrochloride, please let us know.
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Keywords: Pioglitazone hydrochloride, Pioglitazone hydrochloride supplier, PPARg, PPARgamma, PPARγ, peroxisome, proliferator, activated, receptors, nuclear, agonists, antidiabetic, agents, stem, cell, dissociation, cloning, effciency, Receptors, Stem, Cell, Proliferation, 4124, Tocris Bioscience
6 Citations for Pioglitazone hydrochloride
Citations are publications that use Tocris products. Selected citations for Pioglitazone hydrochloride include:
Eunji et al (2023) Inhibition of neuronal peroxisome proliferator-activated receptor-γ attenuates motor function improvement after spinal cord injury in rats. Eur J Neurosci 57 1466-1480 PMID: 36970752
Thakran et al (2015) Pioglit restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. PLoS One 56 177 PMID: 25525174
Helmy et al (2015) Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs. PLoS One 10 e0142303 PMID: 26536032
Byrne et al (2015) Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. J Diabetes Res 2015 752481 PMID: 25759824
Wahlang et al (2014) Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140 283 PMID: 24812009
Merkulova et al (2019) Ponatinib treatment promotes arterial thrombosis and hyperactive platelets. Blood Adv 3 2312 PMID: 31383636
Do you know of a great paper that uses Pioglitazone hydrochloride from Tocris? Please let us know.
Reviews for Pioglitazone hydrochloride
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Pioglitazone hydrochloride promotes macrophage M2 polarization..
By
GAJANAN KATKAR on 12/07/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Bone marrow derived macrophage
Pioglitazone hydrochloride promotes macrophage M2 polarization. To achieve this M0 macrophages BMDM (bone marrow-derived macrophages) stimulated with pioglitazone (5 µm) for 24 h.