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Submit ReviewPirfenidone
Description: Antifibrotic agent; regulates cytokine levels in vivo
Chemical Name: 5-methyl-1-phenyl-2(1H)-pyridinone
Purity: ≥99% (HPLC)
Biological Activity for Pirfenidone
Pirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.
Technical Data for Pirfenidone
| M. Wt | 185.23 |
| Formula | C12H11NO |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 53179-13-8 |
| PubChem ID | 40632 |
| InChI Key | ISWRGOKTTBVCFA-UHFFFAOYSA-N |
| Smiles | CC1=CN(C(=O)C=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pirfenidone
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.7 | 20 |
Preparing Stock Solutions for Pirfenidone
The following data is based on the product molecular weight 185.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 26.99 mL | 134.97 mL | 269.93 mL |
| 1 mM | 5.4 mL | 26.99 mL | 53.99 mL |
| 2 mM | 2.7 mL | 13.5 mL | 26.99 mL |
| 10 mM | 0.54 mL | 2.7 mL | 5.4 mL |
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Product Datasheets for Pirfenidone
References for Pirfenidone
References are publications that support the biological activity of the product.
Iyer et al (1999) Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleo. hamster model of lung fibrosis. J.Pharmacol.Exp.Ther. 289 211 PMID: 10087006
Kehrer and Margolin (1997) Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol.Lett. 90 125 PMID: 9067480
Mei et al (2005) Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. J.Pharmacol.Exp.Ther. 313 379 PMID: 15608079
Oku et al (2002) Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock. Eur.J.Pharmacol. 446 167 PMID: 12098599
If you know of a relevant reference for Pirfenidone, please let us know.
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Keywords: Pirfenidone, Pirfenidone supplier, Antifibrotic, agent, regulates, cytokine, levels, vivo, TNF-α, TNF-alpha, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, esbriet, 1093, Tocris Bioscience
1 Citation for Pirfenidone
Citations are publications that use Tocris products. Selected citations for Pirfenidone include:
Griffiths (2018) Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis. Sci Rep 8 3212 PMID: 29453386
Do you know of a great paper that uses Pirfenidone from Tocris? Please let us know.
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Literature in this Area
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